| Acta Obstet Gynecol Scand 2000 Mar;79(3):180-8
Effects of electro-acupuncture on anovulation in women with polycystic ovary syndrome.
Stener-Victorin E, Waldenstrom U, Tagnfors U, Lundeberg T, Lindstedt G, Janson PO.
Department of Obstetrics and Gynecology, Goteborg University, Sweden.
BACKGROUND: The present study was designed to evaluate if electro-acupuncture
(EA) could affect oligo-/anovulation and related endocrine and neuroendocrine
parameters in women with polycystic ovary syndrome (PCOS). METHODS:
Twenty-four women (between the ages of 24 and 40 years) with PCOS and
oligo-/amenorrhea were included in this non-randomized, longitudinal,
prospective study. The study period was defined as the period extending
from 3 months before the first EA treatment, to 3 months after the last
EA treatment (10-14 treatments), in total 8-9 months. The menstrual
and ovulation patterns were confirmed by recording of vaginal bleedings
and by daily registrations of the basal body temperature (BBT). Blood
samples were collected within a week before the first EA, within a week
after the last EA and 3 months after EA. RESULTS: Nine women (38%) experienced
a good effect. They displayed a mean of 0.66 ovulations/woman and month
in the period during and after the EA period compared to a mean of 0.15
before the EA period (p=0.004). Before EA, women with a good effect
had a significantly lower body-mass index (BMI) (p<0.001), waist-to-hip
circumference ratio (WHR) (p=0.0058), serum testosterone concentration
(p=0.0098), serum testosterone/sex hormone binding globulin (SHBG) ratio
(p=0.011) and serum basal insulin concentration (p=0.0054), and a significantly
higher concentration of serum SHBG (p=0.040) than did those women with
no effect. CONCLUSION: Repeated EA treatments induce regular ovulations
in more than one third of the women with PCOS. The group of women with
good effect had a less androgenic hormonal profile before treatment
and a less pronounced metabolic disturbance compared with the group
with no effect. For this selected group EA offers an alternative to
pharmacological ovulation induction.